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NEOTX ACQUIRES INTERX, ADDS WORLD CLASS DISCOVERY ARM

TEL AVIV and REHOVOT, ISRAEL; MENLO PARK and BERKELEY, CALIFORNIA.  — May 12, 2022 –

NeoTX announced today the acquisition of InterX. InterX, is a drug discovery company utilizing advanced proprietary tools of biomolecular computation for the discovery and design of novel therapeutic molecules based on Nobel Prize Laureate Prof Michael Levitt’s discoveries. These tools allow a detailed quantum mechanical process assessment of biochemical interactions resulting in faster, more accurate and efficient drug discovery. In addition to the discovery engine, this acquisition also comes with a pipeline of early drugs.

“InterX’s technology is the most advanced in the industry, and when combined with the development expertise of NeoTX, we will be able to advance best-in-class drug candidates, increase the value of our pipeline, and strive to contribute to improvement of quality of life within society,” said Nobel Prize Laureate Prof. Roger Kornberg, Chief Scientist of NeoTX and cofounder of InterX. InterX will benefit from the experience and infrastructure of NeoTX while maintaining a culture of innovation and creativity. Post-merger, Prof. Kornberg has also assumed the role of Chairman of the Board of NeoTX.

“We are excited to be expanding NeoTX capabilities to include a suite of proprietary drug discovery technologies. InterX is a world class team that includes three Nobel Laureates who have developed technologies that have the potential to increase the speed of drug discovery. These technologies augment traditional Computer Assisted Drug Discovery (CADD) and are designed to replace much of the typical synthesis and testing cycles that are needed after obtaining results from the traditional CADD process, while potentially saving three-plus years of the typical drug discovery timeline” said CEO, Asher Nathan.

About InterX

InterX is a drug development company, based in the United States and Israel, which is revolutionizing biomolecular computation of chemical and biological systems. The company aims to achieve robust and accurate prediction of molecular and ensemble properties of biological systems using computational methods. InterX is led by Nobel Prize-winning scientist Roger Kornberg. For more information, please visit www.interx.dev

About NeoTX

NeoTX is a clinical-stage company developing targeted anticancer immunotherapies utilizing its proprietary Tumor Targeted Superantigen (TTS) platform. TTS binds a genetically engineered bacterial determinant to the tumor surface while simultaneously activating and expanding tumor specific immune cells that are then redirected from the periphery to the tumor to mount an immune response. The company’s lead TTS molecule, naptumomab estafenatox (NAP) is currently in clinical development for advanced solid tumors. For more information, please visit www.neotx.com

To original press release>>
For further information & collaborations, contact us: info@interx.dev

InterX, Philochem and Scripps Research announce a Research Collaboration in the Field of DNA-Encoded Chemistry and Tumor Targeting

Menlo Park and La Jolla, California, Siena, Italy,  August 23rd, 2021

InterX, Inc., a privately-owned company, Philochem, a wholly owned subsidiary of Philogen S.p.A., a publicly-listed company, and Scripps Research, a non-profit American medical research facility, today announced the signature of a research collaboration to discover new small molecule therapeutics using InterX’s proprietary computational chemical biology software platform and Philochem’s and Scripps’ proprietary DNA-Encoded Chemical Library (DEL) technology.

This collaboration brings together Nobel laureates Roger Kornberg and Michael Levitt with leading DEL technology scientists Richard Lerner and Dario Neri. The team will collaborate on the development of a best-in-class targeting agent for metastatic prostate cancer, a disease that affects millions of patients worldwide.

Prof. Richard Lerner is Institute Professor at Scripps Research, one of the world’s leading Institutions in chemical and biomedical research. He first postulated the principle of DEL technology in 1992.

Philochem is a fully-owned subsidiary of the Philogen group, focused on the development of therapeutic products isolated from DNA-encoded chemical libraries. Philogen is a Swiss-Italian clinical-stage company, listed on the Italian stock exchange (Borsa Italiana). Philochem and Philogen were co-founded by Prof. Dario Neri (the Chief Executive Officer of the company), a pioneer in DEL research and a professor at ETH Zürich. For more information  visit www.philogen.com and www.philochem.com. To original press release>>

For further information & collaborations, contact us: info@interx.dev

selected publications

Pereyaslavets, L., Kurnikov, I., Kamath, G., Butin, O., Illarionov, A., Leontyev, I., Olevanov, M., Levitt, M., Kornberg, R.D., & Fain, B. (2018). On the importance of accounting for nuclear quantum effects in ab initio calibrated force fields in biological simulations. Proceedings of the National Academy of Sciences, 115 (36), 8878-8882.

Kamath, G., Kurnikov, I., Fain, B., Leontyev, I., Illarionov, A., Butin, O., Olevanov, M., Pereyaslavets, L. (2016). Prediction of cyclohexane-water distribution coefficient for SAMPL5 drug-like compounds with the QMPFF3 and ARROW polarizable force fields. Journal of Computer-Aided Molecular Design, 30 (11), 977–988.

Khoruzhii, O., Butin, O., Illarionov, A., Leontyev, I., Olevanov, M., Ozrin, V., Pereyaslavets, L., Fain, B. (2014). Polarizable Force Fields for Proteins. In: Náray-Szabó G. (eds) Protein Modelling. Springer, Cham. 91-134.

Rogen, P., & Fain, B. (2003). Automatic classification of protein structure by using Gauss integrals. Proceedings of the National Academy of Sciences, 100 (1), 119–124.